The study sought to measure the extent to which academic adjustment predicts school attendance among in-school adolescents in Edo state, Nigeria. A correlational design was adopted. Two research questions with corresponding null hypotheses were posed and answered. Data collected from the population of the study consisted of all in-school adolescents in Edo state. A multi stage random sampling procedure was used to draw up a sample consisting of 405 in-school adolescents of both gender; 205 males and 200 females from the three senatorial districts in Edo state. The instrument used for collecting data was questionnaire and school attendance records. Mean scores, Standard Deviation and Peason Product Moment Correlation Analysis was used to answer the research questions while Regression Analysis was used to test the null hypotheses at 0.05 probability level. An overview of the overall results showed that that there exist a direct but moderate positive relationship between academic adjustment and school attendance among in-school adolescents. The result of the study also revealed that academic adjustment significantly predicts school attendance among male and female in-school adolescents. It was therefore recommended Based on the findings among others that all stake holders should create awareness and organise seminars on the implication and impacts of academic adjustment on school attendance. The provisions of necessary facilities in the schools by the government will be of good help in arousing students interest and thus, increasing academic adjustment among in-school adolescents.